On this page is a list of the academic publications I have worked on.
Up-to-date information can also be found at my profiles at Google Scholar, Loop, Researchgate and ORCID.
Preprints / in press
Rupert W Overall, Sara Zocher, Alexander Garthe, Gerd Kempermann. Rtrack: a software package for reproducible automated water maze analysis. bioRxiv
Articles
Senko AN, Overall RW, Silhavy J, Mlejnek P, Malínská H, Hüttl M, Marková I, Fabel KS, Lu L, Stuchlik A, Williams RW, Pravenec M, Kempermann G (2022). Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose. PLOS Genetics 18 e1009638
Leiter O, Zhuo Z, Rust R, Wasielewska JM, Grönnert L, Kowal S, Overall RW, Adusumilli VS, Blackmore DG, Southon A, Ganio K, McDevitt CA, Rund N, Brici D, Mudiyan IA, Sykes AM, Rünker AE, Zocher S, Ayton S, Bush AI, Bartlett PF, Hou S-T, Kempermann G, Walker TL (2022). Selenium Mediates Exercise-Induced Adult Neurogenesis and Reverses Learning Deficits Induced by Hippocampal Injury and Aging. Cell Metabolism 34 1-16
Ostaszewski M, Niarakis A, Mazein A, Kuperstein I, Phair R, Orta-Resendiz A, Singh V, Aghamiri SS, Acencio ML, Glaab E, Ruepp A, Fobo G, Montrone C, Brauner B, Frishman G, Monraz Gómez LC, Somers J, Hoch M, Kumar Gupta S, Scheel J, Borlinghaus H, Czauderna T, Schreiber F, Montagud A, Ponce de Leon M, Funahashi A, Hiki Y, Hiroi N, Yamada TG, Dräger A, Renz A, Naveez M, Bocskei Z, Messina F, Börnigen D, Fergusson L, Conti M, Rameil M, Nakonecnij V, Vanhoefer J, Schmiester L, Wang M, Ackerman EE, Shoemaker JE, Zucker J, Oxford K, Teuton J, Kocakaya E, Summak GY, Hanspers K, Kutmon M, Coort S, Eijssen L, Ehrhart F, Rex DAB, Slenter D, Martens M, Pham N, Haw R, Jassal B, Matthews L, Orlic-Milacic M, Senff Ribeiro A, Rothfels K, Shamovsky V, Stephan R, Sevilla C, Varusai T, Ravel J-M, Fraser R, Ortseifen V, Marchesi S, Gawron P, Smula E, Heirendt L, Satagopam V, Wu G, Riutta A, Golebiewski M, Owen S, Goble C, Hu X, Overall RW, Maier D, Bauch A, Gyori BM, Bachman JA, Vega C, Grouès V, Vazquez M, Porras P, Licata L, Iannuccelli M, Sacco F, Nesterova A, Yuryev A, de Waard A, Turei D, Luna A, Babur O, Soliman S, Valdeolivas A, Esteban-Medina M, Peña-Chilet M, Rian K, Helikar T, Puniya BL, Modos D, Treveil A, Olbei M, De Meulder B, Ballereau S, Dugourd A, Naldi A, Noël V, Calzone L, Sander C, Demir E, Korcsmaros T, Freeman TC, Augé F, Beckmann JS, Hasenauer J, Wolkenhauer O, Wilighagen EL, Pico AR, Evelo CT, Gillespie ME, Stein LD, Hermjakob H, D'Eustachio P, Saez-Rodriguez J, Dopazo J, Valencia A, Kitano H, Barillot E, Auffray C, Balling R, Schneider R, the COVID-19 Disease Map Community (2021). COVID19 Disease Map, a computational knowledge repository of virus-host interaction mechanisms. Molecular Systems Biology 17 e10387
Zocher S, Overall RW, Berdugo-Vega G, Rund N, Karasinsky A, Adusumilli VS, Steinhauer C, Scheibenstock S, Händler K, Schultze JL, Calegari F, Kempermann G (2021). De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis. EMBO Journal e107100.
Zocher S, Overall RW, Lesche M, Dahl A, Kempermann G (2021). Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus. Nature Communications 12 3892.
Ichwan M, Walker TL, Nicola Z, Ludwig-Müller J, Böttcher C, Overall RW, Adusumilli VS, Bulut M, Lugo-Hernández EA, Ramirez-Rodriguez G, Kempermann G (2021). Apple peel and flesh contain pro-neurogenic compounds. Stem Cell Reports 116 2420.
Adusumilli VS, Walker TL, Overall RW, Klatt GM, Zeidan SA, Zocher S, Kirova DG, Ntitsias K, Fischer TJ, Sykes AM, Reinhardt S, Dahl A, Mansfeld J, Rünker AE, and Kempermann G (2021). ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence. Cell Stem Cell 28 (2): 300-314.e6.
Mazein A, Ivanova O, Balaur I, Ostaszewski M, Berzhitskaya M, Serebriyskaya T, Ligon T, Hasenauer J, De Meulder B, Overall RW, Roy L, Knowles RG, Wheelock CE, Dahlen S-E, Chung KF, Adcock IM, Roberts G, Djukanovic R, Pellet J, Gawron P, Balling R, Maitland-van der Zee AH, Schneider R, Sterk PJ, Auffray C, U-BIOPRED Study Group and the eTRIKS Consortium (2020). AsthmaMap: an interactive knowledge repository for mechanisms of asthma. Journal of Allergy and Clinical Immunology 48 916–918.
Zocher S, Schilling S, Grzyb A, Adusumilli VS, Bogado Lopes J, Günther S, Overall RW, Winter Y and Kempermann G (2020). Early-life environmental enrichment generates persistent individualized behavior in mice. Science Advances 6 (35): eabb1478
Bowers M, Liang T, Gonzalez-Bohorquez D, Zocher S, Jaeger BN, Kovacs WJ, Röhrl C, Cramb KML, Winterer J, Kruse M, Dimitrieva S, Overall RW, Wegleiter T, Najmabadi H, Semenkovich CF, Kempermann G, Földy C and Jessberger S (2020). FASN-Dependent Lipid Metabolism Links Neurogenic Stem/Progenitor Cell Activity to Learning and Memory Deficits. Cell Stem Cell 27 (1): 98–109.
Leiter O, Bernas SN, Seidemann S, Overall RW, Horenburg C, Kowal S, Kempermann G and Walker TL (2019). The systemic exercise-released chemokine lymphotactin/XCL1 modulates in vitro adult hippocampal precursor cell proliferation and neuronal differentiation. Scientific Reports 9 11831.
Leiter O, Seidemann S, Overall RW, Ramasz B, Rund N, Schallenberg S, Grinenko T, Wielockx B, Kempermann G and Walker TL (2019). Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation. Stem Cell Reports 12 (4): 667–679.
Overall RW, Balling R, Kempermann G, and Williams RW (2019). Workshop Report: Systems Genetics of Neurodegenerative Disease, a Summer School in Systems Medicine, 25th August−1st September 2017. Frontiers in Genetics 10: 29.
Overall RW and Kempermann G (2018). The Small World of Adult Hippocampal Neurogenesis. Frontiers in Neuroscience 12: 641.
Neuner SM, Garfinkel BP, Wilmott LA, Ignatowska-Jankowska BM, Citri A, Orly J, Lu L, Overall RW, Mulligan MK, Kempermann G, Williams RW, O’Connell KMS and Kaczorowski CC (2016). Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging. Neurobiology of Aging 46: 58–67.
Völkner M, Zschätzsch M, Rostovskaya M, Overall R W, Busskamp V, Anastassiadis K and Karl MO (2016). Retinal Organoids from Pluripotent Stem Cells Efficiently Recapitulate Retinogenesis. Stem Cell Reports 6: 525–538.
Walker TL, Overall RW, Vogler S, Sykes AM, Ruhwald S, Lasse D, Ichwan M, Fabel K and Kempermann G (2016). Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells. Stem Cell Reports 6: 552–565.
Kannan S, Nicola Z, Overall RW, Ichwan M, Ramírez-Rodríguez G, Grzyb AN, Patone G, Saar K, Hubner N and Kempermann G (2016). Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation. Stem Cells 34: 674–684.
Overall RW, Walker TL, Fischer TJ, Brandt MD and Kempermann G (2016). Different Mechanisms Must Be Considered to Explain the Increase in Hippocampal Neural Precursor Cell Proliferation by Physical Activity. Frontiers in Neuroscience 10: 362.
Overall RW, Williams RW and Heimel JA (2015). Collaborative mining of public data resources in neuroinformatics. Frontiers in Neuroscience 9: 90.
Heimel JA, Overall RW and Williams RW (2015). Workshop report: INCF short course on neuroinformatics neurogenomics and brain disease 14–21 September 2013. Frontiers in Neuroscience 9: 31.
Ashbrook DG, Delprato A, Grellmann C, Klein M, Wetzel R, Overall RW and Badea A (2014). Transcript co-variance with Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor cell proliferation in the adult hippocampus. Frontiers in Neuroscience 8: 418.
Fischer TJ, Walker TL, Overall RW, Brandt MD and Kempermann G (2014). Acute effects of wheel running on adult hippocampal precursor cells in mice are not caused by changes in cell cycle length or S phase length. Frontiers in Neuroscience 8: 314.
Ramírez-Rodríguez G, Babu H, Klempin F, Krylyshkina O, Baekelandt V, Gijsbers R, Debyser Z, Overall RW, Nicola Z, Fabel K and Kempermann G (2013). The α crystallin domain of small heat shock protein b8 (Hspb8) acts as survival and differentiation factor in adult hippocampal neurogenesis. Journal of Neuroscience 33: 5785–5796.
Kõks S, Overall RW, Ivask M, Soomets U, Guha M, Vasar E, Fernandes C and Schalkwyk LC (2013). Silencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage. Physiological Genomics 45: 182–190.
Overall RW, Walker TL, Leiter O, Lenke S, Ruhwald S and Kempermann G (2013). Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice. PLoS One 8: e83797.
Stiehler C, Bünger C,Overall RW, Royer L, Schroeder M,Foss M, Besenbacher F, Kruhøffer M, Kassem M, Günther K-P and Stiehler M (2013). Whole-genome expression analysis of human mesenchymal stromal cells exposed to ultrasmooth tantalum vs. titanium oxide surfaces. Cellular and Molecular Bioengineering 6 (2): 199–209.
Overall RW, Paszkowski-Rogacz M and Kempermann G (2012). The mammalian adult neurogenesis gene ontology (MANGO) provides a structural framework for published information on genes regulating adult hippocampal neurogenesis. PLoS One 7: e48527.
Walker TL, Vukovic J, Koudijs MM, Blackmore DG, Mackay EW, Sykes AM, Overall RW, Hamlin AS and Bartlett PF (2012). Prolactin stimulates precursor cells in the adult mouse hippocampus. PLoS One 7: e44371.
Kronenberg G, Gertz K, Overall RW, Harms C, Klein J, Page MM, Stuart JA and Endres M (2011). Folate deficiency increases mtDNA and D-1 mtDNA deletion in aged brain of mice lacking uracil-DNA glycosylase. Experimental Neurology 228: 253–258.
Krebs J, Römer B, Overall RW, Fabel K, Babu H, Brandt MD, Williams RW, Jessberger S and Kempermann G (2011). Adult Hippocampal Neurogenesis and Plasticity in the Infrapyramidal Bundle of the Mossy Fiber Projection: II. Genetic Covariation and Identification of Nos1 as Linking Candidate Gene. Frontiers in Neuroscience 5: 106.
Römer B, Krebs J, Overall RW, Fabel K, Babu H, Overstreet-Wadiche L, Brandt MD, Williams RW, Jessberger S and Kempermann G (2011). Adult hippocampal neurogenesis and plasticity in the infrapyramidal bundle of the mossy fiber projection: I. Co-regulation by activity. Frontiers in Neuroscience 5: 107.
Loguercio S, Overall RW, Michaelson JJ, Wiltshire T, Pletcher MT, Miller BH, Walker JR, Kempermann G, Su AI and Beyer A (2010). Integrative analysis of low- and high-resolution eQTL. PLoS One 5: e13920.
Overall RW, Kempermann G, Peirce J, Lu L, Goldowitz D, Gage FH, Goodwin S, Smit AB, Airey DC, Rosen GD, Schalkwyk LC, Sutter TR, Nowakowski RS, Whatley S and Williams RW (2009). Genetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource. Frontiers in Neuroscience 3: 55.
Jessberger S, Aigner S, Clemenson GD, Toni N, Lie DC, Karalay O, Overall RW, Kempermann G and Gage FH (2008). Cdk5 regulates accurate maturation of newborn granule cells in the adult hippocampus. PLoS Biology 6: e272.
Wolf SA, Kronenberg G, Lehmann K, Blankenship A, Overall RW, Staufenbiel M and Kempermann G (2006). Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer’s disease. Biological Psychiatry 60: 1314–1323.
Arck PC, Overall RW, Spatz K, Liezman C, Handjiski B, Klapp BF, Birch-Machin MA and Peters EMJ (2006). Towards a “free radical theory of graying”: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB Journal 20: 1567–1569.
Peters EMJ, Stieglitz MG, Liezman C, Overall RW, Nakamura M, Hagen E, Klapp BF, Arck P and Paus R (2006). p75 Neurotrophin Receptor-Mediated Signaling Promotes Human Hair Follicle Regression (Catagen). American Journal of Pathology 168: 221–234.
Peters EMJ, Hansen MG, Overall RW, Nakamura M, Pertile P, Klapp BF, Arck PC and Paus R (2005). Control of human hair growth by neurotrophins: brain-derived neurotrophic factor inhibits hair shaft elongation induces catagen and stimulates follicular transforming growth factor beta2 expression. Journal of Investigative Dermatology 124: 675–685.
Chambers SP, Dodd A, Overall RW, Sirey T, Lam LT, Morris GE and Love DR (2001). Dystrophin in adult zebrafish muscle. Biochemical and Biophysical Research Communications 286: 478–483.
Book Chapter
Overall RW (2017). Integrating Multidimensional Data Sources to Identify Genes Regulating Complex Phenotypes. In: Schughart K, Williams R (eds). Methods in Molecular Biology vol 1488. Humana Press New York NY.