Systems biology of adult neural stem cells
Immense advances in our ability to measure and analyse data at scales ranging from molecular to behavioural have meant that unprecedented resources are now available to researchers. I believe that the next challenge is to integrate these data into models which usefully describe the highly complex systems found in biology. In my own field of interest, neural stem cells, for example, an enormous amount is known about genes which control the proliferation of the stem cells and their transition into mature cell types. Nevertheless, we are continually surprised by unexpected new roles of genes and proteins and are still unable to always reliably alter intrinsic programmes - an ability which would have far-reaching clinical consequences.

In my research, I would like to take the next step towards a truly modern biology and explore new techniques to assemble data into a systems-level model of the neural stem cell.